phytobilayer-lb3

A new liposomal form by LaBiotre

Phyto-bioavailability

The plant kingdom is one of the most interesting and promising sources of active molecules. Most of the plant-derived classes of active compounds have a lipophilic, or hydro-insoluble molecular structure. The direct consequence of this is a limited bioavailability.

 
  • Lipophilic
  • Water insoluble
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Poorly available
Compromised effectiveness
 

A branded technology to improve

 
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Solubility

Thanks to phospholipids bilayer coating
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Bioavailability

Thanks to enhanced affinity for mucosas (hydrophilic external layer)
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Taste masking

Thanks to the excipient pool ideated for the coating
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Stability

Thanks to the excipient pool ideated for the coating

The technology

Liposomes are spherical particle showing at least one lipid bilayer, composed of phospholipids so that the inner and the outer surface are hydrophilic. and this enable a better solubility in hy- dro-medium. Phytobilayer technology of production has been proven to modify the structure of raw material from crystalline to micellar with consequent benefits in terms of bioavailiabilty and solubility.
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Immagini SEM di attivo cristallino (ingrandimento 500X)

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Immagini SEM di attivo cristallino (ingrandimento 1500X)

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Immagini SEM di attivo PHYTOBILAYER LB3® (ingrandimento 100X)

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Immagini SEM di attivo PHYTOBILAYER LB3® (ingrandimento 500X)

Our results: bioavailability of liposomal berberine

Berberine, an active alkaloid from Berberis aristata, Is well known to be poorly available for enteric absorption. In this study on animal model, the Berberin quantity in mouse blood samples has been evaluated at 10, 30, 60, 120 and 480 minutes from the oral administration via gavage of 50 mg/Kg of a formulation of Labiotre with 20% of berberine Phytobilayer, and berberine 97% hydrochloride used as a monitor. Both were suspended in water at a concentration of 12.5 mg / mL of equivalent berberine and used for oral administration with berberine equidosage.
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5 times more available at 60 min

A versatile technology

Phytobilayer Technology is highly customizable in

Active ingredients

  • Herbal extracts
  • Aminoacid and peptides
  • Vitamines and minerals

Coating excipients

Different phospholipidic molecules can be used for the coating

Coating thickness

Coating process can be modulated to gain diffe- rent particle size